What are MAOIs?

MAOIs - monoamine oxidase inhibitors - are old generation antidepressants, Parnate (tranylcypromine) and Nardil (phenelzine) being the best known. They work by blocking the enzyme monoamine oxidase, which allows the neurotransmitters to function as usual. Side effects can be very burdensome, which make these drugs a last option. These include an outside risk of hypertension, which necessitates extreme dietary restrictions. Some psychiatrists, however, believe these drugs work particularly well for atypical depression, and should be regarded as a viable treatment option. Somerset Pharmaceuticals is experimenting with Seligeline as a transdermal patch that is not supposed to have the usual MAOI side effects.