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What is Navane?

Navane (Thiothixene) [thigh-oh-THICKS-een]
What is Navane Use For?

This medication is used to treat a certain mental/mood disorder (schizophrenia). Navane can improve the symptoms of schizophrenia, making it easier to function in everyday life. It belongs to a class of drugs known as antipsychotics. It works by affecting the balance of certain chemicals in the brain.
How Should Navane Be Taken?

Take this medication by mouth with or without food, usually 1-3 times daily or as directed by your doctor. Dosage is based on your medical condition and response to therapy. Your doctor may start you at a low dose and gradually increase your dose over several weeks. Follow your doctor's instructions carefully. This medication does not work right away. It may take up to 2-3 weeks before you experience the full benefits. Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Do not stop taking this medication without consulting your doctor. Your condition may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. Inform your doctor if your condition persists or worsens.
What Are The Side Effects?

Drowsiness, dizziness, dry mouth, blurred vision, tiredness, nausea, constipation, stuffy nose, increased thirstiness, and trouble sleeping may occur. Rarely, you may also be more sensitive to sunburn and less able to tolerate heat/strenuous exercise (see Precautions section). If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication for longer time periods may develop serious side effects, but with frequent visits to your doctor, this risk can be minimized. Tell your doctor immediately if any of these unlikely but serious side effects occur: feelings of restlessness/agitation/jitteriness, mask-like facial expression, shuffling walk, drooling, uncontrolled shaking of the hands, twitching in the face, muscle spasm/weakness, trouble swallowing, uncontrollable movements of the mouth/face/hands, unusual mental/mood changes (e.g., depression, worsening of psychosis), trouble urinating, severe constipation, unexplained weight gain, increased appetite, loss of appetite, swelling of the feet/ankles, nipple discharge, unusual breast milk production, swollen/tender breasts, changes in menstrual flow, decreased sexual ability, darkening of skin color, fainting. For males, in the very unlikely event you have a painful, prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention or permanent problems could occur. Tell your doctor immediately if any of these rare but very serious side effects occur: irregular heartbeat, seizures, easy bruising/bleeding. This drug may infrequently cause a serious (sometimes fatal) nervous system problem (neuroleptic malignant syndrome). Seek immediate medical attention if you notice any of the following rare but very serious side effects: fever, rigid muscles, increased sweating, fast heartbeat, mental/mood changes, change in the amount of urine. A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088. In Canada, you may call Health Canada at 1-866-234-2345.
Is There Any Special Precautions?

Before taking Navane, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you frequently take alcohol/narcotics to become intoxicated. Navane should also not be used in those who are in a coma (unable to wake up) or in shock (unconscious with severely low blood pressure). This medication should not be used in a patient who is unconscious. Before using this medication, tell your doctor or pharmacist your medical history, especially of: breast cancer, seizure disorder, certain heart problems (e.g., angina), heart rhythm problems, very high or low blood pressure, blood disorders (e.g., low white or red blood cells), severe liver problems. This drug may make you dizzy or drowsy or cause blurred vision. Use caution while driving, using machinery, or doing any activity that requires alertness and clear vision. Avoid alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. This medication may rarely make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Wear sunblock (SPF 30 or greater) and a hat when outdoors. Caution is advised during hot weather because Navane may rarely decrease your ability to sweat, leading to fever or heatstroke. Drink plenty of fluids and dress lightly. Avoid strenuous exercise in hot weather. If you become overheated, promptly seek cooler shelter and/or stop exercising. Seek immediate medical attention if your body temperature is above normal or if you have mental/mood changes, headache, or dizziness. Facial/muscle twitching and uncontrollable movements (tardive dyskinesia) may occur with this medication and may be permanent. It is not known which people are at risk of having this effect become irreversible. The risk may be greater with large doses and prolonged use of this medication. Discuss ways to minimize this risk with your doctor. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially drowsiness, dizziness (which may increase the risk of falls), and the development of uncontrolled movements (e.g., tardive dyskinesia). Caution is advised when using this drug in children because they may be more sensitive to the effects of the drug. During pregnancy, this medication should be used only when clearly needed. Infants exposed to this medication during pregnancy may develop muscle/movement problems. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
What Are The Drug Interactions?

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. This drug should not be used with the following medications because very serious interactions may occur: sibutramine, cabergoline, pergolide. If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting thiothixene. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: lithium, carbamazepine, ropinirole. Also tell your doctor if you take any drugs that might increase your risk of a seizure when combined with Navane, such as bupropion, isoniazid (INH), phenothiazines (e.g., thioridazine, chlorpromazine), theophylline, tramadol, and tricyclic antidepressants (e.g., amitriptyline), among others. Consult your doctor or pharmacist for details. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
What Do I Do I Case Of An Overdose?

If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: muscle twitching, severe drowsiness/dizziness, rigid state, weakness, shakiness, drooling, inability to wake up (coma).
What Else Should I Know?

Do not share this medication with others. Do not miss medical and laboratory test appointments. Laboratory and/or medical tests (e.g., liver function, eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
What Happens If I Miss A Dose?

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Is There A Special Warning With Navane?

There may be a slightly increased risk of serious, possibly fatal side effects (e.g., pneumonia, heart failure) when this medication is used in older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
What If I Have More Questions?

This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product is safe, effective, or appropriate for you.
Medical Alert:
Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).