What is Thorazine?

Chlorpromazine

Thorazine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) and other psychotic disorders (conditions that cause difficulty telling the difference between things or ideas that are real and things or ideas that are not real) and to treat the symptoms of mania (frenzied, abnormally excited mood) in people who have bipolar disorder (manic depressive disorder; a condition that causes episodes of mania, episodes of depression, and other abnormal moods). Thorazine is also used to treat severe behavior problems such as explosive, aggressive behavior and hyperactivity in children 1-12 years of age. Thorazine is also used to control nausea and vomiting, to relieve hiccups that have lasted one month or longer, and to relieve restlessness and nervousness that may occur just before surgery. Thorazine is also used to treat acute intermittent porphyria (condition in which certain natural substances build up in the body and cause stomach pain, changes in thinking and behavior, and other symptoms). Thorazine is also used along with other medications to treat tetanus (a serious infection that may cause tightening of the muscles, especially the jaw muscle). Thorazine is in a class of medications called conventional antipsychotics. It works by changing the activity of certain natural substances in the brain and other parts of the body.

How should Thorazine be used?

Thorazine comes as a tablet to take by mouth. Thorazine is usually taken two to four times a day. When Thorazine is used to control nausea and vomiting, it is usually taken every 4-6 hours as needed. When Thorazine is used to relieve nervousness before surgery, it is usually taken 2-3 hours before surgery. When Thorazine is used to relieve hiccups, it is usually taken 3-4 times a day for up to 3 days or until the hiccups stop. If the hiccups do not stop after 3 days of treatment, a different medication should be used. If you are taking Thorazine on a regular schedule, take it at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Thorazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of Thorazine and gradually increase your dose. Your doctor may decrease your dose once your condition is controlled. Be sure to tell your doctor how you are feeling during your treatment with Thorazine.

If you are taking Thorazine to treat schizophrenia or another psychotic disorder, Thorazine may control your symptoms but will not cure your condition. Continue to take Thorazine even if you feel well. Do not stop taking Thorazine without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking Thorazine, you may experience withdrawal symptoms, such as nausea, vomiting, stomach pain, dizziness, and shakiness.

Other uses for Thorazine

Thorazine may be prescribed for other uses; talk to your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Thorazine,

tell your doctor and pharmacist if you are allergic to Thorazine; other phenothiazines such as fluphenazine, perphenazine, Compazine, Phenergan, thioridazine, and trifluoperazine; or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin); antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal); cancer chemotherapy; diuretics (water pills); epinephrine (Epipen); guanethidine (not available in the US); ipratropium (Atrovent); lithium (Eskalith, Lithobid); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; medications for seizures such as phenytoin (Dilantin); narcotic medications for pain; propranolol (Inderal); sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had asthma; emphysema (a lung disease that causes shortness of breath); an infection in your lungs or bronchial tubes (tubes that bring air to the lungs); glaucoma (condition in which increased pressure in the eye can lead to gradual loss of vision); breast cancer; pheochromocytoma (tumor on a small gland near the kidneys); seizures; an abnormal electroencephalogram (EEG; test that records electrical activity in the brain); any condition that affects the production of blood cells by your bone marrow; or heart, liver, or kidney disease. Also tell your doctor if you have ever had to stop taking a medication for mental illness due to severe side effects or if you plan to work with organophosphorus insecticides (a type of chemical used to kill insects).
if you will be using Thorazine to treat nausea and vomiting, it is important to tell your doctor about any other symptoms you are experiencing, especially listlessness; drowsiness; confusion; aggression; seizures; headaches; problems with vision, hearing, speech, or balance; stomach pain or cramps; or constipation. Nausea and vomiting that is experienced along with these symptoms may be a sign of a more serious condition that should not be treated with Thorazine.
tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking Thorazine, call your doctor. Thorazine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking chlorpromazine.
if you are having a myelogram (x-ray examination of the spine), tell your doctor and the radiographer that you are taking Thorazine. Your doctor will probably tell you not to take Thorazine for 2 days before the myelogram and for one day after the myelogram.
you should know that this medication may make you drowsy and may affect your thinking and movements. Do not drive a car or operate machinery until you know how this medication affects you.
ask your doctor about the safe use of alcohol during your treatment with Thorazine. Alcohol can make the side effects of Thorazine worse.

•plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Thorazine may make your skin sensitive to sunlight.
you should know that Thorazine may cause dizziness, lightheadedness, fast heartbeat, and fainting, especially when you get up too quickly from a lying position. This is most common at the beginning of treatment with Thorazine, especially after the first dose. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that Thorazine may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you are taking Thorazine on a regular schedule and you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Thorazine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness
blank facial expression
shuffling walk
restlessness
agitation
nervousness
unusual, slowed, or uncontrollable movements of any part of the body
difficulty falling asleep or staying asleep
increased appetite
weight gain
breast milk production
breast enlargement
missed menstrual periods
decreased sexual ability
changes in skin color
dry mouth
stuffed nose
difficulty urinating
widening or narrowing of the pupils (black circles in the middle of the eyes)

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

fever
muscle stiffness
confusion
fast or irregular heartbeat
sweating
yellowing of the skin or eyes
flu-like symptoms
sore throat, chills, and other signs of infection
unusual bleeding or bruising
neck cramps
tongue that sticks out of the mouth
tightness in the throat
difficulty breathing or swallowing
fine, worm-like tongue movements
uncontrollable, rhythmic face, mouth, or jaw movements
seizures
blisters
rash
hives
itching
swelling of the eyes, face, mouth, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
vision loss, especially at night
seeing everything with a brown tint

If you experience a serious side effect, you or your doctor may phone [1-800-332-1088].

Thorazine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

What storage conditions are needed for Thorazine?

Keep Thorazine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

sleepiness
loss of consciousness
unusual, slowed, or uncontrollable movements of any part of the body
agitation
restlessness
fever
seizures
dry mouth
irregular heartbeat

What other information should I know?

Keep all appointments with your doctor and your eye doctor. You should have regularly scheduled eye exams during your treatment with Thorazine because Thorazine may cause eye disease.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Thorazine.

Thorazine may interfere with the results of home pregnancy tests. Talk to your doctor if you think you might be pregnant during your treatment with Thorazine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Older adults with dementia

Thorazine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking Thorazine. For more information, visit the FDA website.

Warning

Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as chlorpromazine have an increased chance of death during treatment.